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Research indicates that probiotic strains, by improving gut microbiota, can increase the expression of BDNF in the brain, thereby ameliorating depressive-like behavior (Zhang et al., 2023)

128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing

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Int J Radiat Oncol Biol Phys 71(4):1261-71, 2008

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Guyer RD: Mini-Invasive 360 and Indirect Decompression for Spondylolisthesis