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A third proposed mechanism of action is based upon the observation that polyamines accumulate in the synovium of patients with RA and that metabolism of these polyamines by macrophages leads to the production of toxic oxygen products that diminish stimulated T-cell function [2527]

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The Head-Up Tilt table test as a measure of autonomic functioning among patients with myalgic Encephalomyelitis/Chronic fatigue syndrome

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10.1016/j.psj.2023.102773 83 LuC

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Figure 4C illustrates the shortest pathway through which polyphenolic compounds Gallic acid, Myricetin, Quercetin, Apigenin, and Kaempferol interact with key molecular targets, Hydroxysteroid 17Beta Dehydrogenase 10 (HSD17B10) and Transthyretin (TTR), to exert their therapeutic effects

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This suggests that while an increase in mitophagy may occur as an initial adaptive response to mitochondrial injury, long-term metabolic insults could overwhelm the capacity for quality control by mitophagy

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doi: 10.1590/1806-9282.64.12.1122 285 SheaSSheaSHiltonMFHiltonMFOrlovaCAyersRTet al

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