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When side effects do occur, they are typically mild and may include: Mild gastrointestinal symptoms such as nausea, diarrhoea, or upset stomach, particularly when starting supplementation or taking high doses on an empty stomach Skin reactions including itching, rash, or a sensation of swelling, though these are uncommon Headache or dizziness in some individuals, particularly with intramuscular injections Injection site reactions (pain, redness, or swelling) when B12 is administered via intramuscular injection for deficiency treatment It is important to note that serious adverse effects are rare

Nonetheless, it seems that it could have intracellular targets instead of only being proteolysed

Pain scores (VAS, WOMAC) showed numerical but not statistically significant improvements in most trials

Variables such as family history and lifestyle choices make it difficult for researchers to directly link alcohol to specific diseases, except for conditions that have a strong causal link to alcohol use such as alcoholic fatty liver disease, says Anastasia Jandes, M.D

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