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Begin with The amino acid precursor to norepinephrine, a Tryptophan Folic acid 0.5 g/day and increase grad- mood-elevating neurotransmitter.6,7 Should be Vitamin B complex Vitamin B12 ually to a dose that produces taken with 50 mg vitamin B6 improvement 13 g Can increase levels of brain serotonin, a mood- elevating neurotransmitter.3,5,8 Should be taken with 50 mg vitamin B6 0.8 mg-5.0 g Can increase methylation reactions in the brain that may elevate mood.9,10 May increase response to serotonin-uptake inhibitors10 Containing at least 25 mg of Marginal deficiencies of thiamin, riboflavin, niacin, thiamin, riboflavin, niacin, and and pyridoxine can produce depression11,12 pyridoxine 1 mg/week by intramuscular Particularly effective in older people with fatigue injection and depression13,14 Score 3 2 Schizophrenic, placebo 1 Schizophrenic, folate Depression, placebo Depression, folate 0 01 2 34 5 6 Time (mo) Fig

Kostova V, Dsos P, Starck JB, Kotschy A