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This process was fundamental in order to buffer ROS flux and a consequent detrimental over increase of self-digestion ( Figure 2 )

H.IslamK.KenneyJ.NielsenM

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases

However, its conversion to 5-fluoro-2 deoxy-5 monophosphate (FdUMP) leads to the inhibition of thymoadenylate synthetase (TS) and subsequent DNA synthesis, which is thought to be its primary mechanism of action

Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress