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Briefly, lung tissues were minced and digested with collagenase I (1 mg/mL) at 37 C for 60 min, then filtered through 70-m cell strainers

For instance, mitochondrial ROS activate the NLRP3 inflammasome to drive pyroptosis, while TGF- and ROS form a self-amplifying loop that accelerates fibrotic progression

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Another pathway in inhibition of TGF--mediated EMT by curcumin is that this plant derived-natural compound suppresses Smad2 phosphorylation, its nuclear translocation and interaction with promoter of Snail (Cao et al., 2017)

10.1016/0006-291X(88)90482-2 Biochem

Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk