Buchheit, Holt, Sheu, et al
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The CFAX12 platform presented in this study offers significant advantages over traditional models that typically utilize cigarette smoke extract (CSE) treatment and culture cells under submerged conditions, which do not accurately represent the ALI conditions found in the human lung 45,46
Damaged mitochondria slow down and make less energy, reducing the efficacy and efficiency of bodily functions
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To assess if the injected anti-NIP IgG1s triggered immunogenicity under the conditions tested, mouse anti-human IgG responses were measured by ELISA, which revealed only a minor response in mice receiving mAb4-WT but not in animals that received NIP-WT, NIP-REW or mAb4-REW when compared to pre-bleed samples (Fig