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T., Cheng, Y., Chang, Y

96 MBK-103 (LY4170156) comprises an Fc-attenuated humanized IgG1 antibody targeting FR and a novel polysarcosine hydrophilic masking entity, allowing the conjugation of the exatecan payload with a DAR of 8 97 (Figure 4)

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Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1/PPAR pathway-mediated fatty acid oxidation

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Mechanistically, GHK-Cu counteracts UV-induced damage through multiple pathways: suppression of UV-stimulated MMP-1 expression prevents ongoing collagen degradation, enhancement of collagen synthesis repairs existing deficits in dermal matrix density, and antioxidant properties reduce accumulation of oxidatively modified proteins and lipids