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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Maiorino M., Conrad M., Ursini F

Continued use furthers steady lightening

Levodopa remains the most effective agent for controlling motor symptoms, but its long-term use leads to motor complications, reduced efficacy, and treatment resistance ( 5.1 Levodopa and the rationale for combination therapy Levodopa, often co-administered with carbidopa to inhibit peripheral metabolism, is the gold standard for PD treatment

Hence, vitamin D might regulate a wide range of physiological and pathological processes, including vascular cell growth, migration, and differentiation, immune response modulation, and inflammatory pathways in the blood vessels (147)