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It neutralizes lipid peroxidation chain reactions by donating a hydrogen atom to lipid peroxyl radicals, forming relatively unreactive tocopheroxyl radicals

Th1 cells typically have a pro-atherosclerotic effect, while Tregs exhibit anti-atherosclerotic properties

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ROS accumulation occurs in GCLC-deficient T cells, where excessive ROS impairs mTOR activation, affecting the expression of c-MYC and nuclear factor of activated T cells (NFAT), and adversely impacts T cell metabolic reprogramming

Jungert et al., 2020) and in Canadian women of reproductive age and younger Irish adults (40% vs 52%