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Insulin/IGF-1/PI3K/AKT/mTOR pathway Insulin/IGF-1/PI3K/AKT/mTOR pathway and aging The insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) pathway, a highly conserved nutrient-sensing mechanism, was the first signaling pathway demonstrated to regulate both aging processes and susceptibility to age-related diseases in model organisms

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