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Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]

Bipolar disorder (BD) is a common, chronic, and devastating psychiatric disorder affecting 2-3% of the global population, characterized by recurrent episodes of depression and/or (hypo)mania, and accompanied by significant cognitive and social impairment, which brings a heavy disease burden to patients, families and society

278 ROS-mediated Ca 2+ activation in antitumorigenic signaling involves the potentiation of the Ca 2+ emission channel mucolipin-1 (MCOLN1/TRPML1) through palmitoylation of cysteine residues Cys565, Cys566, and Cys567 within the L564CCC motif on its C-terminal tail

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Based on the integrated assessment of imaging, histopathology, and IHC findings, a definitive primary site could not be established, and the case was therefore diagnosed as carcinoma of unknown primary (CUP) with multiple-organ metastasis

Glutathione: Overview of its protective roles