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In pediatric class 3 patients, ablation of the expanded thalassemic marrow and stronger immunosuppression through the use of an intensified preparation regimen including HU, azathioprine, fludarabine and hypertransfusion increased event-free survival to 8085% [90], [91]

Targeted interventions addressing these sources led to a 35% improvement in reproductive function markers among previously exposed individuals (134)

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Many surgical patients have subclinical nutritional deficiencies that don't cause obvious symptoms but significantly impair healing capacity