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Plant Physiol Biochem 167:6876

A lot of the papers looking at these drugs and their impact on immunity have shown that people who take them respond better to infections, they have better outcomes in the context of fighting different types of cancer, but no one has looked at what is directly happening to the immune cells, says Claire Pillsbury, PhD, a postdoctoral fellow working in the lab of cancer center leader Curtis Henry, PhD

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We find that drugs that inhibit generation of glutamate by the glutathione cycle elicit decreases in cytosolic glutamate and decreased miniature excitatory postsynaptic potential (mEPSC) frequency

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ROS oxidize GSH into GSSG, which reacts with cysteinyl residues (-SH) on proteins to form PSSG