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Description

Translational Neurodegeneration

Min He, [email protected]

Previous studies in ophthalmology have indicated that aberrant DNA methylation disrupts the expression of key genes, such as RHO, OPN1LW and TUBA1A (227,228), contributing to the pathogenesis of various ocular diseases, such as corneal and conjunctival disorders, glaucoma (229), cataracts (230), retinal diseases (231), and ocular tumours (232)

Microbiome-targeted interventions like probiotics and diet have shown potential to modulate immune activity and may reduce disease activity, though more robust clinical evidence is needed

employed Western blot analysis to demonstrate that HIF-1 expression in myocardial tissues from the I/R group peaked at 2 h post-reperfusion, with concurrent upregulation of TfR and Tf levels mirroring the HIF-1 elevation [85]