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As we push the boundaries of what's possible in cellular longevity and senescence, compounds like FOXO4-DRI have certainly captured significant attention

It has been shown to inhibit apoptosis and cell death in primary cardiomyocyte and endothelial cell cultures (352), to have varying effects on the proliferation of various prostate carcinoma cell lines (353), to inhibit isoproterenol-induced lipolysis in rat adipocyte cultures (354), and to induce hypotension and bradycardia when injected into the nucleus tractus solitarii of rats (355)

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In summary, glutamine uptake and metabolism have a tight connection with mTOR signaling

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