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Data availability All data generated that support the findings of this study are present in the main text and the Supplementary Information file

(i) Extrafollicular B-cell responses generate an early antibody response within a few days without time-consuming SHM and without inducing immunological memory in terms of long-term antibody production or MBCs

Melanin is the pigment responsible for skin colour, and inhibiting its production can result in a lighter complexion

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Mutation Prevalence and Upgrade Rate to Cancer Among Patients with Pleomorphic and Florid Lobular Carcinoma in Situ and Germline Pathogenic Variant Cancer Predisposition Genes, Laboratory Investigation