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(Lond.) 38 , 63 (2018)

For instance, people with chronic illnesses or those who take medications affecting liver function should talk to healthcare providers about their diet

The first double formulation, consisting in a combination of Ivacaftor and Lumacaftor (Orkambi, Vertex Pharmaceuticals Ltd, UK), have been approved in 2015 by FDA and EMA for patients who are homozygous for the F508del CFTR mutation