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Watanabe, Fumiko, et al

doi: 10.1002/advs.201500053 141 NagayamaAVidulaNEllisenLBardiaA

234 MTAP is located in the periphery of the tumor suppressor cyclin-dependent kinase inhibitor 2 A (CDNK2A), and the co-deletion of the two genes occurs in ~15% of cancers and results in a highly aggressive tumor with a poor prognosis

doi: 10.1007/s12393-024-09394-2 131

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In our opinion, further carefully designed studies are still necessary for substantiating this view and supporting optimum procedures in terms of both efficacy and safety profiles