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The states problem is not the worst in the nation actually the state ranks in the middle of the pack but significant gaps in prevention and treatment for drug addiction remain, according to experts

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Short Communications Exacerbation of Kaposi sarcoma following BRAF/MEK inhibitor therapy in a melanoma patient: a case report and mechanistic insight Antonios Tsimpidakis a Ioannis-Alexios Koumprentziotis a Evanthia Mastoraki a Michaella Plaka a Helen Gogas b Alexander Stratigos a Vasiliki Nikolaou a Melanoma Research 34(5):p 469-471, October 2024

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[15] [13] Other notable adverse effects include: Hypoglycemia : Low risk when used as monotherapy, but increased when combined with insulin or sulfonylureas Injection site reactions : Erythema, pruritus, or discomfort in approximately 2% to 4% of patients Fatigue and dizziness : Reported in 5% to 8% of participants Increased heart rate : Mean increases of 2 to 4 beats per minute observed [1] [2] Serious adverse events were uncommon but included acute pancreatitis (approximately 0.2% incidence), gallbladder disease including cholecystitis and cholelithiasis (0.6% in diabetes trials and up to 2.5% in weight management trials, associated with rapid weight loss), and acute kidney injury, typically in the context of severe dehydration from gastrointestinal symptoms