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We saw wonderful effects in terms of reducing neurodegeneration and neuroinflammatory responses, and even rescuing behavior deficits. With further testing, the researchers hope that the peptide could eventually be used as a treatment for patients with Alzheimers disease and other forms of dementia that have CDK5 overactivation

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It serves as a required substrate for enzymes such as sirtuins and poly(ADP-ribose) polymerases (PARPs). Sirtuins regulate cellular stress responses, metabolic homeostasis, and genomic stability, while PARPs play a central role in detecting DNA damage and initiating repair processes

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