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Additionally, the reduced plasma levels of brain-derived neurotrophic factor (BDNF) observed in BIPN patients may be associated with BTZ-mediated inhibition of platelet aggregation and activation, which in turn leads to decreased BDNF release and consequently impairs its neuroregenerative effects on peripheral nerves (Nishiwaki et al., 2020)

Cascone T, William Jr WN, Weissferdt A, Leung CH, Federico L, Haymaker C, Bernatchez C, Fossella FV, Mott FE, Papadimitrakopoulou VA, Byers LA, Lam VK, Godoy MC, Lee JJ, Vaporciyan A, Givvons DL, Swisher SG , Heymach JV, Sepesi B

8 , eabm3381 (2022)

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Epitalon: A pineal-derived peptide shown to regulate melatonin and telomerase activity, supporting circadian rhythm and cellular longevity

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