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It is nonessential for most humans, but may be essential in infants, the elderly and individuals who suffer from certain metabolic diseases

10.21037/tau.2019.08.09 69 MontorsiF.OelkeM.HennegesC.BrockG.SaloniaA.dAnzeoG.et al (2016)

Specific BAs have been shown to directly influence the differentiation, activation, and effector functions of key innate and adaptive immune cell populations, highlighting a direct mechanistic link between microbial metabolism and anti-tumor immunity

For example, in muscle, IRS-1 is more related to glucose uptake whereas IRS-2 stimulates the MAPK pathway [121]

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We find that Xpa-/- and Xpc-/- mouse livers accumulate mutations which we term SBS-NER-KO, a mutational signature resembling SBS8, which has an unknown mechanism but is likely driven by endogenous NER substrates