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1 Introduction Osteoarthritis (OA) is one of the most common forms of arthritis, affecting over 500 million people worldwide, and damage to articular cartilage is one of the most prevalent pathological changes in OA ( Articular cartilage is an avascular, aneural, and alymphatic tissue ( However, the role of immune cells in cartilage damage during OA remains controversial in existing research, with debates over whether they act as foes or friends

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Similarly, Iwata and colleagues suppressed Drp1 expression by in utero electroporation using short hairpin RNA at E13.5 and observed a decrease in the proportion of generated neurons and an increase in the proportion of intermediate progenitors and RGCs [78]