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2024 Jul 13];74(4):476-86

Chang, A.I

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For affinity fusion proteins, the appended protein will bind to a third, typically small, molecule that is immobilized on the surface of a polymer resin

Its core mechanism involves actively depleting glucose within the tumor microenvironment (TME), thereby disrupting the dysfunctional Warburg effect that tumor cells rely upon while simultaneously remodeling the immune microenvironment