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doi: 10.1038/s41586-019-1484-9 304 ShengW

Date of Issue : 2025-08-22 Valid Till : 2028-08-21 Written Confirmation Number : WC-0099 Address of the Firm : NDC Package Code : 15308-2402 Start Marketing Date : 2024-01-31 End Marketing Date : 2026-12-31 Dosage Form (Strength) : POWDER (200kg/200kg) Marketing Category : BULK INGREDIENT USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization

Gentle, non-habit-forming

Trends Cell Biol 1:3942 Kehrer JP (1993) Free radicals as mediators of tissue injury and disease

Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity