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Ohno et al., 2021) in astrocytes revealed that the dysfunction of the BBB initiates hyperactivation of transforming growth factor beta (TGFB/TGF-) signaling, which is vital to elicit neuronal dysfunction and age-related neuropathology (Senatorov et al., 2019

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Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies

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Accordingly, increasing GSH synthesis and release in astrocytes by overexpression or pharmacological activation of Nrf2 protected cocultured naive neurons from oxidative glutamate toxicity, whereas inhibition of glial GSH synthesis/release abolished glial-mediated neuronal protection 62

In poultry, HS has been associated with reduced feed consumption, growth, feed efficiency, quantity and quality of eggs produced, meat quality, reproductive performance, impaired gut health, and increased mortality