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CONCLUSION Although reactive oxygen species are essential for some reproductive processes such as capacitation and acrosome reaction, increased ROS along with decreased antioxidant defense result in OS status which ultimately leads to sperm membrane lipid peroxidation, reduced motility, sperm DNA damage, poor pregnancy, and ART outcomes and increased risk of genetic diseases in offspring

There is clear evidence that the gut microbiota directly influences UC occurrence, and the abnormal intestinal mucosal barrier will change the composition of pathogenic microorganisms, toxicity and invasiveness, and further aggravate inflammation

The preferred embodiment includes the variations of the amount of glutathione to create less concentrated amounts of glutathione

and (2) Forward causation (unproven in humans)IS drives tubular injury

however, understanding the exact role of zinc in this mechanism requires further studies (Hara et al., 2023[182])

Sensors Actuators B Chem