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Based on available research, the recommended doses of 5-HTP are: Depression: 50-100mg, 3 times per day with food Insomnia: 100-300mg, 30-45 minutes before bedtime Fibromyalgia : 100mg, 3-4 times per day with food Headaches: 100200mg, 2-3 times per day with food Weight loss /management: 250300mg, 30 minutes before meals These are the recommended ranges

Then in 2019, a meta-analysis study tried to clarify the OS marker profile in ALS patients: the authors demonstrated that 8-OHdG and MDA were significantly increased in the peripheral blood of ALS patients when compared with control subjects, while GSH levels were significantly reduced