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doi: 10.1111/j.1748-5827.2001.tb01799.x

Among them, the PTEN/PI3K/mTOR signaling pathway has been shown to be involved in macrophage repolarization, such as porous hollow iron oxide nanoparticles PHNP@3-MA loaded with P13K small molecule inhibitors modified with mannose can target TAMs, and PHNPs combined with 3-MA can activate the inflammatory factor NF-B p65 of macrophages thereby converting TAMs into pro-inflammatory M1 macrophages, activating immune responses and inhibiting tumor growth in vivo ( 45, 46)

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MMWR Morb Mortal Wkly Rep 64:421423 Stabler SP (2013) Clinical practice

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