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In lyophilized form, they are shelf-stable for many weeks

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Disinfect the rubber stoppers of both vials (peptide + BAC water) with a disinfection wipe (70 % isopropyl alcohol)

3 Gently swirl do not shake

Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms

B) Profiles of the 24 hours continuous glucose monitoring for each treatment group In terms of secondary outcome measures and adverse events, the results of the study reported that all treatment groups experienced significant reductions in total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol