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found that nuclear PHGDH facilitates tumor growth in conditions of nutritional stress, with the phosphorylation levels of PHGDH-Ser371 and PHGDH-Ser55 correlating with the activity of p38 and AMPK, respectively, in human pancreatic cancer clinical samples

Supplementation with the reduced form of coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice

10.1152/ajpgi.00531.2006 122 SongX.LiJ.WangY.ZhouC.ZhangZ.ShenM.et al (2019)

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However, ascorbate accumulation was completely blocked in the D dhar pad2-1 quadruple mutants , which consistently showed bleaching, lower photochemical activity and a higher accumulation of threonate in response to high light

It helps protect your cells from oxidative stress caused by free radicals