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Iron abundance, proneness to oxidative stress, the role of Ca 2+ signaling in cell death, and the capability of other erythroid lineage cells to undergo ferroptosis all together indicate that this iron-driven cell death pathway might exist in RBCs

We attempted to overcome these limitations by focusing on a single pathway, using an information-based gene-selection algorithm (based on location in autism linkage regions and expression patterns), selecting tag-single-nucleotide polymorphisms (SNPs) to achieve very high coverage of genes and flanking regions, and by evaluating high order genegene interactions using a newly developed method adapted for family data

Nat Rev Immunol 11(2):119130 Capon F (2017) The genetic basis of psoriasis