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Fan L, Zhu X, Sun S, Yu C, Huang X, Ness R, Dugan LL, Shu L, Seidner DL, Murff HJ, et al

imbalances in gut bacteria change neurotransmitter function and alter immune response, resulting in associated inflammatory activation.13 In susceptible individuals, its possible that a leaky gut may set the stage for a leaky blood-brain barrier with mind-altering consequences.14 In addition, a poorly nourished microbiome due to a highly processed, low-fiber diet can result in decreased production of short-chain fatty acids such as butyrate, which has been shown to be neuroprotective.15 What this means for the RD is that assessing a patients gut health is critical to evaluating their mental health

J Nutr 139(3):452460

Wilson Disease and low ceruloplasmin Ceruloplasmin A multi-copper blood ferroxidase involved in iron and copper homeostasis and inflammation

Psychiatry 99, 109836

The temporal association between starting tirzepatide and experiencing hot flashes does not necessarily indicate causation