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Serratia secondary metabolite prodigiosin inhibits Pseudomonas aeruginosa biofilm development by producing reactive oxygen species that damage biological molecules

We found that dietary Met supplementation significantly decreased the relative mRNA expression levels of Nrf2 and NF-B as well as the phosphorylation level of NF-B, increased the levels of downstream antioxidant enzymes HO-1 and NQO-1 in the hippocampi, normalized the levels of inflammatory cytokines in the plasma and hippocampi (IL-1, IL-6, TNF-, and IL-10), and further decreased the expression levels of apoptosis-related genes, including Caspase 3 and Bax (Figs

PE-22-28 targets the TREK-1 potassium channel, producing fast-acting antidepressant and anxiolytic effects through a unique mechanism

In some cases, it can increase the potency

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Kaweme NM, Zhou S, Changwe G J, et al