glutathione synthetase requires REGULATION OF SYNTHESIS Glutathione Synthetase Deficiency as a

Neurosci Biobehav Rev (2013) 37(10):255463

Zhang X, Irajizad E, Hoffman KL, Fahrmann JF, Li F, Seo YD, Browman GJ, Dennison JB, Vykoukal J, Luna PN, Siu W, Wu R, Murage E, Ajami NJ, McQuade JL, Wargo JA, Long JP, Do KA, Lampe JW, Basen-Engquist KM, Okhuysen PC, Kopetz S , Hanash SM, Petrosino JF, Scheet P, Daniel CR

Gu et al., 2003) have shown that the activation of M1-mAChR promotes the -secretase-mediated cleavage of APP, thereby inhibiting its cleavage by BACE-1 and -secretase to produce neurotoxic A, and can significantly reduce A excitatory neurotoxicity (action potential firing and excitatory postsynaptic currents)

Genes Genom

Ophtalmate, a product of -ketobutyrate metabolism, regulates transporters and enzymes involved in GSH uptake, efflux, and metabolism (Schomakers et al., 2024)

Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, Kiani J, Zaare M, Najafipoor F