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In many cases, what is interpreted as angiogenic activity may instead reflect other forms of vascular remodelingsuch as BBB disruption, pericyte loss, or basement membrane alterationsrather than true neovascularization

The dose increase at week 3 often marks the point where patients first clearly feel the difference

Rare reports of hospitalization and/or dialysis or fatal outcome occurred in patients with underlying moderate to severe renal impairment or with any of the risk factors described in this section [see Adverse Reactions (6.2)]

Still, its important to note that even then, most people with a family history do not develop the disease

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