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RT-qPCR analyses validated the upregulation of ATF4 target genes, including SLC1A1, SLC7A8 , phosphoserine aminotransferase 1 ( PSAT1 ), and serine hydroxymethyltransferase 2 ( SHMT2 ) in T315I-Bcr-Abl cells (Fig

This could mechanistically result from ibrutinib-induced mitochondrial dysfunction and redox imbalance, both of which are known to activate IRP1/2

demonstrated that the granulosa cells from women with PCOS and from a mouse model exhibited ER stress and mediated ferroptosis in granulosa cells, leading to follicular dysfunction induced by HA

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A similar result was obtained for the production of H 2 S 2 and H 2 S 3

14, 15, 16, 17, 18, 19, 20 GSH is a representative non-enzymatic antioxidant that exists at low intracellular levels and functions as an important regulator of redox balance and oxidative stress