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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)

if anything, tolerability concerns argue for going slower

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Research indicates that approximately 80% of individuals with hypothyroidism have Hashimoto's anti bodies, but this statistic can vary based on environmental factors and individual health conditions

doi: 10.1016/j.ando.2018.09.004

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