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Nature medicine 18 , 10281040 (2012)

These effects usually resolve within a few days of starting or adjusting the concentration

Song J, Wang H, Sheng J, Zhang W, Lei J, Gan W, et al

Insulin autoimmune syndrome: Three case reports

Elegant experiments revealed that much of the glutamine dependence of cancer cell lines is driven by the superphysiologic concentration of cystine in standard growth media: in these cells high cystine drives the cystine/glutamate antiporter xCT to import cystine and excrete glutamate, and the cells must then import glutamine to maintain intracellular glutamate