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Despite these benefits, NPs show some toxicity to human tissues and cells depending on their various properties such as size [174], shape, functional surfaces [170] and concentration [175]

Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG et al (2003) The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

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In general, intestinal barrier can be categorized into four components: the mechanical, immune, chemical, and biological barriers

Brown NC, Andreazza AC, Young LT