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In hair cells, autophagy plays an important role in preventing ototoxicity, including aminoglycoside-, cisplatin-, noise-, and age-induced hearing loss (Mizushima et al

J Exp Ther Oncol 3(3):346362

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3503-C A PHASE 2a, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE SAFETY, TOLERABILITY, EFFICACY, AND PHARMACOKINETICS OF INT-787 IN SUBJECTS WITH SEVERE ALCOHOL-ASSOCIATED HEPATITIS: STUDY DESIGN, OBJECTIVES, AND NOVEL ASSESSMENTS Thomas Capozza, Steven Lauder, Sam Madison and Jennifer Callahan, Intercept Pharmaceuticals, Inc., Morristown, NJ Background: Severe alcohol-associated hepatitis (sAH) is the most acute and serious form of alcohol-associated liver disease

This work was supported by the National Institutes of Health [grant numbers HG007690, HL061795, HL155107, GM107618]