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The requirement for B vitamins varies significantly throughout life, especially during pregnancy, breastfeeding, and as individuals age

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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

Yen explained to MNT: Our preclinical studies suggest that NASH patients who have pernicious anaemia, gastritis, prior gastric bypass surgery, diabetes and taking metformin, or are vegetarians with low folate/B12 intake are several populations that may be at potential risk for worsened NASH

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