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The shRNA sequences (Supplementary Table 1) were synthesized by Genewiz (Tianjin, China) and inserted into pLKO.1-TRC vector (Addgene #10879)

Nanoscale 9, 349354

Among the key genes implicated in this process are tyrosinase (TYR), tyrosinaserelated protein 1 (TYRP1), tyrosinaserelated protein 2 (TYRP2), microphthalmiaassociated transcription factor (MITF), paired box gene 3 (Pax3), SRYbox transcription factor 10 (Sox10), melanocortin 1 receptor (MC1R), tyrosine kinase receptor (cKit), Plexin C1 (Plexin C1), MelanA (MelanA), premelanosome protein (Pmel17), and the receptor for hepatocyte growth factor (MET)

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Challenges remain, like balancing supplementation to avoid toxicity, but the potential for personalized medicine based on GPx profiles excites researchers

By supporting collagen production and cellular repair, it helps protect the skin from oxidative damage caused by UV rays and pollution