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High-affinity interaction of ACE2 and/or NRP1 with the RBD of viral S-protein, followed by cell-mediated furin pre-activation could effectively facilitate host cellular entry of SARS-CoV-2 while evading host immune surveillance 67

At the same time, or due to higher mitochondrial activity, apoE4 is more inflammatory, which is characterized by chemokine production, immune cell adhesion and higher sensitivity of innate receptors to activation (Marottoli et al., 2021)

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The increase of IL-23 expression was positively correlated with the expression levels of macrophage markers (e.g., CD11c, CD68, and CD86), pro-inflammatory cytokines (e.g., TNF-, IL-12, IL-18), and chemokines [e.g., C-X-C motif chemokine ligand 8 (CXCL8), CCL5, and CCL20] [29]

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The GRK4 65L allele is associated with impaired renal sodium handling in response to stress in Black normotensive adolescents [117]