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Conclusion: Current evidence does not demonstrate a statistically significant protective effect of antioxidant therapy against AMS

Preclinical Toxicology: Toxicity studies in rodents indicate that even high doses (e.g., 20 mg/kg) do not result in gross organ toxicity or lethality in the acute setting

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"Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis." N Engl J Med