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PDH catalyzes the formation of acetyl coenzyme A, a crucial step in energy production, and, through acetyl-CoA, serves as a precursor for acetylcholine (ACh), which is vital for nerve signal transmission and muscle function since ACh acts on the communication between neurons and in the neuromuscular junction, as well as for myelin production in nerve cells (40)

The first conjugation event involves the covalent attachment of Atg12 to Atg5, which requires Atg7 and Atg10 acting as E1 and E2-like enzymes, respectively

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