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These synthetic micro/nanomotors autonomously move by converting chemical 33,34 , acoustic 35 , optical 36 , electrical 37 and magnetic 38 energy into mechanical energy, and follow the environmental cues towards areas of higher chemical fuel concentration 39,40 , which holds promise for precision medicine 41

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A declined expression of NRF2 and its corresponding genes has been observed in AD brains

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Data availability The Cryo-EM density maps and associated masks have been deposited in the EMDB under accession number EMD-63371, EMD-63372, EMD-63374, EMD-63375, EMD-63397, EMD-63383, EMD-63385, and EMD-63386, EMD-63565, and EMD-65758