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Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease

JNK activation turns on LPS- and gram-negative bacteria-induced NADPH oxidase-dependent suicidal NETosis

doi: 10.1155/2020/6627144

The phenolic hydroxyl group and other functional groups in its chemical structure give it a certain biological activity, but also affect its stability

Using the oxaliplatin model of CIPN, it has also been demonstrated that the increased expression of CC chemokine ligand 2 (CCL2) and its receptor, CCR2, in the dorsal root ganglia was lowered after intrathecal administration of anti-CCL2 antibodies, which prevented the development of oxaliplatin-induced mechanical hypersensitivity [137]

Furthermore, SFN treatment increased nuclear NRF2 levels, and simultaneously decreased the level of cytoplasmic NRF2, suggesting SFN increased nuclear NRF2 activity [108]