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Post-mortem brain tissue from AD patients and transgenic mouse models (e.g., APP/PS1, 5xFAD) consistently shows significant downregulation of glutathione peroxidase 4 protein expression, accompanied by characteristic ferroptotic morphological alterations such as mitochondrial shrinkage (189)

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This can lead to reduced physiological responses to melatonin, worsening the consequences of its decrease

Additionally, ID significantly reduces CD4+ T cell proliferation and cell cycle progression, contributing to the reduced number of circulating T cells (94)

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